doi: 10.1152/ajpheart.00301.2008īischkopf J, Busse A, Angermeyer MC (2002) Mild cognitive impairment-a review of prevalence, incidence and outcome according to current approaches. Am J Physiol Heart circulatory physiol 295(3):H962–H968. This further strengthens the relationship between autonomic dysfunction and cognitive disorders.īaumert M, Lambert GW, Dawood T, Lambert EA, Esler MD, McGrane M, Barton D, Nalivaiko E (2008) QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder. Reduced HRV is significantly associated with lower cognitive performance at a population level in people aged 50 and older.

Sub-domains of MOCA responsible for the relationship were predominantly memory recall and language. Lower quintiles of SDNN ( P = 0.01-paced), LF ( P = 0.001-paced), and LF:HF ratio ( P = 0.049-paced) were significantly associated with lower MOCA scores (during both recording periods), independent of confounders. Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index, after adjustment for covariates. HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment (MOCA) score. A subset of 4,763 participants who underwent ECG recording during resting and paced breathing periods were used for the analysis. MethodsĬross-sectional analysis of wave 1 data from the Irish longitudinal study on ageing (TILDA) was performed. To examine the independent association between heart rate variability (HRV) and cognitive performance, in a nationally representative population study of older adults.

Longitudinal moca cognitive assessment